朱晨辉

朱晨辉

西北老员工物工程系副主任、教授、博士生导师、三级教授;

陕西省生物材料与发酵工程技术研究中心,副主任;

陕西省可降解生物医用材料重点实验室,副主任;

E-mail: zch2005@nwu.edu.cn






主要研究领域:

主要从事药用多肽、重组蛋白及天然活性产物的绿色生物制造,聚焦其生物合成、分离纯化、生物学功效及免疫学特性,实现了从“基础研究——功能发现——产业化——应用”的全链条研究,研究领域涉及合成生物学、生物医用材料、组织工程、预防医学和营养医学、抗肿瘤新药等。


教育经历:

1.访问学者,杜克老员工物医学工程系,2012.08-2013.08

2.博士,生物化工专业,伟德国际1949官网, 2005.09 -2008.12

3.硕士,化学工程专业,伟德国际1949官网,2002.09-2005.07

4.学士,微生物制药专业,沈阳药科大学,1992.09 -1996.07


学术机构任职:

1.陕西省生物化学与分子生物学学会,理事,2016.12-至今;

2.陕西省化工学会生物化工专业委员会,委员,2009.12-至今;

3.陕西省中小企业专家顾问团专家,2010.12-至今

4.中国化工学会女科技工作者委员会委员,2021.9-至今

5.中国生物材料学会会员,2012.09-至今


主要获奖:

1.2017年,“全长人胶原蛋白的发酵合成及应用”,陕西省科学技术奖一等奖;

2.2016年,“系列新型湿性修复敷料的研制与应用”,中国石油和化学工业联合会科学技术奖一等奖;

3.2013年,“类人胶原蛋白生物材料的创制及应用”,国家技术发明奖二等奖;

4.2011年,“新型胶原蛋白生物材料关键生产技术与应用”,陕西省科学技术奖一等奖。


个人荣誉:

1.2016年,“陕西省中青年科技创新领军人才”;

2.2016年,第十一届陕西青年科技奖;

3.2015年,“西安市学术技术带头人培养人选”;

4.多次获得“伟德国际1949官网优秀教师”。


代表性论文 :

1. Yang Li, Rongzhan Fu, ZhiguangDuan, Chenhui Zhu*, Daidi Fan. Artificial Non-Enzymatic Antioxidant MXeneNanosheets-Anchored Injectable Hydrogel as Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing. ACS nano, 2022, 16:7486-7502SCI I top, IF 18.027

2. Yang Li, Rongzhan Fu, ZhiguangDuan, Chenhui Zhu*, Daidi Fan*. Injectable Hydrogel Based on Defect-Rich Multi-Nanozymes for Diabetic Wound Healing via an Oxygen Self-Supplying Cascade Reaction. Small, 2022(18):18. SCI I top, IF 15.153

3. Wanyi Zhou, ZhiguangDuan, Jing Zhao,Rongzhan Fu*,Chenhui Zhu*, Daidi Fan*. Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing, Bioactive Materials,2022(11): 17. (SCI, I top IF16.874

4. Zhang Bo, Fu Rongzhan, DuanZhiguang, Shen Shihong, Zhu Chenhui*, Fan Daidi*. Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism[J]. Biochemical Pharmacology, 2022, 202: 115101SCI IItop, IF 6.1

5. Yang Li, Rongzhan Fu, ZhiguangDuan, Chenhui Zhu*, Daidi Fan*. Adaptive Hydrogels Based on Nanozyme with Dual-Enhanced Triple Enzyme-Like Activities for Wound Disinfection and Mimicking Antioxidant Defense System.Advanced Healthcare Materials, 2021, 2101849, DOI: 10.1002/adhm.202101849, SCI Itop, IF 9.933

6. Yang Li, Rongzhan Fu, ZhiguangDuan, Chenhui Zhu*, Daidi Fan, Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS2 dual nanozyme for bacteria-infected wound healing. Bioactive Materials, 2022, 9, 461-474SCI, I top,IF 14.593

7. Yang Li, Rongzhan Fu, Chenhui Zhu*, Daidi Fan, An antibacterial bilayer hydrogel modified by tannic acid with oxidation resistance and adhesiveness to accelerate wound repair. Colloids and Surfaces B: Biointerfaces 205 (2021) 111869(SCI, II top , IF 5.268)

8.Yang Li, Rongzhan Fu, Chenhui Zhu*, Daidi Fan. Mussel-inspired adhesive bilayer hydrogels for bacteria-infected woundhealing via NIR-enhanced nanozyme therapy.Colloids and Surfaces B: Biointerfaces 210 (2022) 112230 (SCI, II top , IF 5.268)

9. Xue Bai,;Rongzhan Fu, ZhiguangDuan, Yannan Liu,Chenhui Zhu*, Daidi Fan. Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition. Food & Function 2021, 12 (7), 2874-2885. (SCI, I top, IF 5.396)

10.Xue Bai, Rongzhan Fu, ZhiguangDuan , Pan Wang, Chenhui Zhu*, Daidi Fan. Ginsenoside Rk3 alleviates gut microbiotadysbiosis and colonic inflammation in antibiotic-treated mice. Food Research International, 2021, 146, 110465. (SCI, II, IF 6.475)

11. Xuqian DengJiaqi Zhao, Linlin Qu, ZhiguangDuan, Rongzhan Fu, Chenhui Zhu*,Daidi Fan*.Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.Biochemical Pharmacology. 2020,178:114038-114056. SCI, II top, IF 5.858

12. Mimi Xing, Rongzhan Fu,Yannan Liu, Pan Wang, Pei Ma,Chenhui Zhu * and Daidi Fan*.Human-like collagen promotes the healing ofacetic acid-induced gastric ulcers in rats byregulating NOS and growth factors.Food &Function.2020, 11(5) 4123-4137. SCI, I top, IF 5.396

13. Minxia Zhang, Jiaqi Zhao, Jianjun Deng, ZhiguangDuan, Chenhui Zhu *, Daidi Fan *.The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice. Food&Function.2019, 10(7):4124-4133.SCI, I top, IF 5.396.


专著或专著章节:

1. Smart Materials for Tissue Engineering》,ROYAL SOCIETY OF CHEMISTRY出版社,2017年,参编第二十章;

2. 《化学工程-从基础研究到工业应用》,化学工业出版社,2015年,编写第九章第四节。


主持国家级科研项目

1.药用多肽绿色生物制造关键技术与产业示范(课题2“药用多肽高效分离、纯化关键技术”负责人),国家重点研发计划(2021YFC2103900),2021.12-2025.12;

2.用于黑色素瘤治疗及皮肤组织再生的新型可注射双功效水凝胶,国家自然基金(22178287),2022.1-2025.12;

3.人造蛋白质合成的细胞设计构建及应用(课题4“蛋白材料装配加工与应用”子课题负责人),国家重点研发计划(2019YFA0905200), 2020.1-2024.12;

4.孔径可控pH敏感双层互穿网络水凝胶敷料的分子设计及构建策略,国家自然基金(21878247),2019.1-2022.12;

5.新型磷酸化胶原蛋白铁复合物的形成及其吸收机理,国家自然基金(21576222),2016.1-2019.12;

6.国家自然基金(青年基金),国家自然科学基金委,小口径同轴共纺血管支架过程参数对其生物学特性的影响规律,2013.01-2015.12。